ADO Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-15460-20UL
60 ul
£183.00
E-AB-15460-60UL
120 ul
£272.00
E-AB-15460-120UL
200 ul
£420.00
E-AB-15460-200UL
About this Product
- SKU:
- E-AB-15460
- Additional Names:
- 2 aminoethanethiol dioxygenase;2-aminoethanethiol dioxygenase;ADO;ADO 2 aminoethanethiol (cysteamine) dioxygenase;AEDO;C10orf22;Chromosome 10 open reasing frame 22;Cysteamine dioxygenase;DKFZp564C046;FLJ14;cysteamine (2-aminoethanethiol) dioxygenase (ADO)
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.3 mg/ml
- Extra Details:
- Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human ADO
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ado_polyclonal_antibody-e_ab_15460
