CPSF4 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-14891-20UL
60 ul
£183.00
E-AB-14891-60UL
120 ul
£272.00
E-AB-14891-120UL
200 ul
£420.00
E-AB-14891-200UL
About this Product
- SKU:
- E-AB-14891
- Additional Names:
- 30kD,30kDa,CPSF 30 kDa subunit,CPSF30,Cleavage and polyadenylation specificity factor 30 kDa subunit,Cleavage and polyadenylation specificity factor subunit 4,Cpsf4,cleavage and polyadenylation specific factor 4,cleavage polyadenylation specificity factor
- Application:
- Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.4 mg/ml
- Extra Details:
- Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human CPSF4
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cpsf4_polyclonal_antibody-e_ab_14891
