GNAS Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-14088-20UL
60 ul
£183.00
E-AB-14088-60UL
120 ul
£272.00
E-AB-14088-120UL
200 ul
£420.00
E-AB-14088-200UL
About this Product
- SKU:
- E-AB-14088
- Additional Names:
- AHO;C20orf45;GNAS1;GPSA;GSA;GSP;NESP;PHP1A;PHP1B;PHP1C;POH
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 0.4 mg/ml
- Extra Details:
- This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human GNAS
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-gnas_polyclonal_antibody-e_ab_14088
