COX10 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-13841-20UL
60 ul
£183.00
E-AB-13841-60UL
120 ul
£272.00
E-AB-13841-120UL
200 ul
£420.00
E-AB-13841-200UL
About this Product
- SKU:
- E-AB-13841
- Additional Names:
- 2410004F01Rik,AU042636,COX10,Cytochrome c oxidase assembly protein,Cytochrome c oxidase subunit X,Heme A farnesyltransferase,Heme O synthase,OTTMUSP00000006085,Protoheme IX farnesyltransferase,mitochond,mitochondrial
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.4 mg/ml
- Extra Details:
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human COX10
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cox10_polyclonal_antibody-e_ab_13841
