DIO2 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-13198-20UL
60 ul
£183.00
E-AB-13198-60UL
120 ul
£272.00
E-AB-13198-120UL
200 ul
£420.00
E-AB-13198-200UL
About this Product
- SKU:
- E-AB-13198
- Additional Names:
- 5DII,D2,DIO2,DIOII,Deiodinase,EC 1.97.1.10,IOD2,ITDI2,SelY,TXDI2,Thyroxine deiodinase,Type 2 DI,Type 2 iodothyronine deiodinase,Type II 5' deiodinase,Type II iodothyronine deiodinase,Type-II 5''-deiodinase,iodothyronine,type II
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.9 mg/ml
- Extra Details:
- The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human DIO2
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-dio2_polyclonal_antibody-e_ab_13198
