PTTG1 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-12630-20UL
60 ul
£183.00
E-AB-12630-60UL
120 ul
£272.00
E-AB-12630-120UL
200 ul
£420.00
E-AB-12630-200UL
About this Product
- SKU:
- E-AB-12630
- Additional Names:
- EAP1,HPTTG,PTTG,TUTR1
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.3 mg/ml
- Extra Details:
- The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human PTTG1
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-pttg1_polyclonal_antibody-e_ab_12630
