CASP12 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-12302-20UL
60 ul
£183.00
E-AB-12302-60UL
120 ul
£272.00
E-AB-12302-120UL
200 ul
£420.00
E-AB-12302-200UL
About this Product
- SKU:
- E-AB-12302
- Additional Names:
- CASP 12,CASP-12,CASP12P1,CASPC,Casp12,Inactive caspase-12,OTTHUMP00000207032,caspase 12 (gene/pseudogene),caspase 12 pseudogene 1
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.3 mg/ml
- Extra Details:
- Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human CASP12
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-casp12_polyclonal_antibody-e_ab_12302
