DDIT4 Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-11148-20UL
60 ul
£183.00
E-AB-11148-60UL
120 ul
£272.00
E-AB-11148-120UL
200 ul
£420.00
E-AB-11148-200UL
About this Product
- SKU:
- E-AB-11148
- Additional Names:
- DDIT4,DNA damage inducible transcript 4,DNA damage inducible transcript 4 protein,DNA damage-inducible transcript 4 protein,Dig2,FLJ20500,HIF 1 responsive RTP801,HIF 1 responsive protein RTP801,HIF-1 responsive protein RTP801,Protein regulated in de
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.8 mg/ml
- Extra Details:
- REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human DDIT4
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-ddit4_polyclonal_antibody-e_ab_11148
