pVHL Polyclonal Antibody
Product Sizes
20 ul
£118.00
E-AB-10671-20UL
60 ul
£183.00
E-AB-10671-60UL
120 ul
£272.00
E-AB-10671-120UL
200 ul
£420.00
E-AB-10671-200UL
About this Product
- SKU:
- E-AB-10671
- Additional Names:
- E3 ubiquitin pro,Elongin binding protein,G7 protein,HRCA 1,HRCA1,Protein G7,RCA 1,RCA1,VHL,VHL 1,VHL1,VHLH,Von Hippel Lindau disease tumor suppressor,Von Hippel Lindau tumor suppressor,pVHL,von Hippel Lindau syndrome,von Hippel Lindau tumor suppressor
- Application:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Clonality:
- Polyclonal
- Concentration:
- 0.4 mg/ml
- Extra Details:
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human VHL
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-pvhl_polyclonal_antibody-e_ab_10671
