IL-17A Polyclonal Antibody
Product Sizes
25 ul
£134.00
D-AB-10452L-25UL
100 ul
£291.00
D-AB-10452L-100UL
About this Product
- SKU:
- D-AB-10452L
- Additional Names:
- Cytotoxic T-lymphocyte-associated antigen;IL17A;CTLA-8;CTLA8;IL-17;IL-17A;IL17;Interleukin-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA 8;CTLA8;CTLA-8;CTLA8cytotoxic T-lymphocyte-associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL17;IL-17;IL17A;IL-17A;IL-17Acytotoxic T-lymphocyte-associated protein 8;IL-17CTLA-8;Cytotoxic T lymphocyte associated antigen 8;Cytotoxic T lymphocyte associated protein 8;Cytotoxic T lymphocyte associated serine esterase 8;IL 17A;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);Interleukin 17A;Interleukin17;Interleukin17A;OTTHUMP00000016597;OTTMUSP00000046003
- Application:
- Immunohistochemistry
- Buffer:
- PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human IL-17A protein expressed by E.coli
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-il_17a_polyclonal_antibody-d_ab_10452l
