MIG Gamma/CXCL9 Polyclonal Antibody
Product Sizes
25 ul
£134.00
D-AB-10440L-25UL
100 ul
£291.00
D-AB-10440L-100UL
About this Product
- SKU:
- D-AB-10440L
- Additional Names:
- C-X-C motif chemokine 9,Cxcl9,Gamma-interferon-induced monokine,Mig,Monokine induced by interferon-gamma (MIG,MuMIG),Protein m119,Scyb9,Small-inducible cytokine B9
- Application:
- Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Chemokine (C-X-C motif) ligand 9 (CXCL9),also known as Monokine induced by gamma interferon (MIG),is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined,however,it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG,together with CXCL10 and CXCL11,may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth,movement,or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all,and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV,MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG,and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse MIG Gamma/CXCL9 protein expressed by E.coli
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:cxcl9_polyclonal_antibody-d_ab_10440l
