CellaQuant[TM] Rat IL-4 (Interleukin 4) ELISA Kit
Product Sizes
24 tests
£143.00
CQR007-24TESTS
48 tests
£295.00
CQR007-48TESTS
96 tests
£356.00
CQR007-96TESTS
About this Product
- SKU:
- CQR007
- Additional Names:
- B cell growth factor 1,BCDF,B-cell stimulatory factor 1,BCGF1,BCGF-1,binetrakin,BSF1,BSF-1,IL4,IL-4,IL-4B_cell stimulatory factor 1,IL4E12,interleukin 4,interleukin-4,Lymphocyte stimulatory factor 1
- Application:
- ELISA
- Extra Details:
- Human Interleukin-4 (IL-4) is a pleiotropic cytokine primarily produced by Th2-polarized CD4+ T cells, mast cells, basophils, and eosinophils. It is the master regulator of type 2 immunity, driving the differentiation of naive CD4+ T cells into Th2 cells, thereby creating a self-amplifying loop that secretes IL-4, IL-5, and IL-13 to promote humoral immunity while suppressing Th1-mediated cellular responses. For B cells, IL-4 acts as a co-stimulator for proliferation and directs immunoglobulin class switching to IgE and IgG4. It also upregulates MHC class II molecules on B cells and enhances expression of the low-affinity IgE receptor (CD23) on lymphocytes and monocytes. Furthermore, IL-4 primes and recruits mast cells, basophils, and eosinophils, stimulating epithelial cell proliferation and activating macrophages by increasing IL31RA expression. It induces autophagy in dendritic cells via mTORC1 inhibition and RUFY4 induction. IL-4 signals through two receptor complexes: the type I receptor (IL-4RA Alpha and common G Gamma-chain) on hematopoietic cells, and the type II receptor (IL-4RA Alpha and IL-13RA Alpha1) on non-hematopoietic cells, which also mediates IL-13 signaling. Its dominant role in promoting IgE production and allergic inflammation makes it a critical therapeutic target in conditions like asthma and atopic dermatitis.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Range:
- 15.63-1000 pg/mL
- Reactivities:
- Rat
- Sensitivity:
- 7.85 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-cellaquant™_rat_il_4_(interleukin_4)_elisa_kit-cqr007
