CellaQuant[TM] Mouse TNF-A Alpha (Tumor Necrosis Factor Alpha) ELISA Kit
Product Sizes
24 tests
£143.00
CQM002-24TESTS
48 tests
£295.00
CQM002-48TESTS
96 tests
£356.00
CQM002-96TESTS
About this Product
- SKU:
- CQM002
- Additional Names:
- DIF,TNF-alpha,TNFA,TNFSF2,TNF,TNFa
- Application:
- ELISA
- Extra Details:
- Tumor Necrosis Factor-alpha (TNF-A Alpha), also known as cachectin or TNFSF1A, is the prototypic ligand of the Tumor Necrosis Factor superfamily. As a pleiotropic cytokine, TNF-A Alpha plays a central role in immunity, inflammation, and metabolic homeostasis. Its functions are primarily mediated by two receptors, TNFR1 and TNFR2, which activate signaling pathways such as NF-K KappaB and MAPK to regulate a broad spectrum of cellular responses. In terms of immunity, TNF-A Alpha activates innate immune cells including macrophages and neutrophils, promotes the release of inflammatory cytokines such as IL-1 and IL-6, and modulates the activation and differentiation of T and B lymphocytes. In tissue homeostasis, TNF-A Alpha can induce apoptosis in target cells while also promoting cell survival via NF-K KappaB signaling, under certain conditions, it also contributes to the induction of necroptosis. Metabolically, TNF-A Alpha inhibits lipoprotein lipase activity, leading to cachexia, and is involved in the development of insulin resistance. Dysregulation of TNF-A Alpha is closely associated with a variety of diseases, including autoimmune disorders such as rheumatoid arthritis and Crohn's disease, asthma, neuropathic pain, obesity and type 2 diabetes, septic shock, and the progression of various cancers. Human TNF-A Alpha is initially synthesized as a 26 kDa type II transmembrane protein, consisting of an intracellular domain of 35 amino acids, a transmembrane segment of 21 amino acids, and an extracellular domain of 177 amino acids. It is produced by a wide range of immune cells (such as macrophages and T cells), epithelial cells, endothelial cells, and certain tumor cells.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Range:
- 15.63-1000 pg/mL
- Reactivities:
- Mouse
- Sensitivity:
- 9.40 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-cellaquant™_mouse_tnf_α_(tumor_necrosis_factor_alpha)_elisa_kit-cqm002
