CellaQuant[TM] Human IL-12 (Interleukin 12) ELISA Kit
Product Sizes
24 tests
£134.00
CQH019-24TESTS
48 tests
£270.00
CQH019-48TESTS
96 tests
£325.00
CQH019-96TESTS
About this Product
- SKU:
- CQH019
- Additional Names:
- Interleukin-12 subunit alpha,IL-12A,NKSF1,NK cell stimulatory factor chain 1
- Application:
- ELISA
- Extra Details:
- IL-12 p70 is the biologically active heterodimer of interleukin-12 (IL-12), consisting of disulfide-linked IL-12A (p35) and IL-12B (p40) subunits with a molecular weight of approximately 70 kDa. It is primarily produced by professional antigen-presenting cells (APCs) following antigen stimulation, which distinguishes it from inactive p40 monomers or homodimers. Functionally, IL-12 p70 induces interferon-gamma (IFN-G Gamma) production, promotes the differentiation of naive T cells into T-helper 1 (Th1) cells, and enhances the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). It exerts its effects by binding to the IL12RB Beta1/B Beta2 heterodimeric receptor, which activates JAK-STAT4 signaling to regulate cytokine-responsive gene expression.IL-12 p70 shares the p40 subunit with IL-23 and the p35 subunit with IL-35. As a key link between innate and adaptive immunity, it plays a vital role in research on infectious diseases, autoimmune disorders, and cancer immunotherapy.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Range:
- 1.25-80 pg/mL
- Reactivities:
- Human
- Sensitivity:
- 0.75 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-cellaquant™_human_il_12_(interleukin_12)_elisa_kit-cqh019
