CellaQuant[TM] Human IL-23 (Interleukin 23) ELISA Kit
Product Sizes
24 tests
£143.00
CQH013-24TESTS
48 tests
£388.00
CQH013-48TESTS
96 tests
£473.00
CQH013-96TESTS
About this Product
- SKU:
- CQH013
- Additional Names:
- IL23,IL-23,IL-23A,IL-23-A,IL-23p19,interleukin 23, alpha subunit p19,interleukin-23 subunit alpha,Interleukin-23 subunit p19,JKA3 induced upon T-cell activation
- Application:
- ELISA
- Extra Details:
- Interleukin-23 (IL-23) is a heterodimeric cytokine pivotal in bridging innate and adaptive immunity. It is composed of two disulfide-linked subunits: a unique p19 subunit (IL-23A) and a p40 subunit (IL-12B) shared with IL-12. While p19 is expressed by various activated immune and endothelial cells, the concurrent expression of p40-primarily by activated macrophages and dendritic cells-is the critical limiting step for functional IL-23 production.IL-23 signals through a heterodimeric receptor complex consisting of IL-12RB Beta1 and the IL-23-specific IL-23R. This interaction activates the JAK2/STAT signaling cascade, leading to phosphorylation of STAT1, STAT3, STAT4, and STAT5.Functionally, IL-23 has distinct roles from IL-12. Its action is largely restricted to memory T cells, driving their proliferation and, crucially, their production of the potent pro-inflammatory cytokine IL-17. This IL-23/IL-17 axis is a central mediator of inflammatory and autoimmune pathogenesis. Additionally, IL-23 can enhance immunogenic antigen presentation by CD8+ dendritic cells. Thus, IL-23 is a key regulator of inflammatory responses, critically involved in host defense, autoimmune diseases, and tumor immunology.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Range:
- 31.25-2000 pg/mL
- Reactivities:
- Human
- Sensitivity:
- 18.75 pg/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-cellaquant™_human_il_23_(interleukin_23)_elisa_kit-cqh013
