CellaQuant[TM] TGF-B Beta1 (Transforming Growth Factor Beta 1) ELISA Kit
Product Sizes
24 tests
£155.00
CQ001-24TESTS
48 tests
£325.00
CQ001-48TESTS
96 tests
£360.00
CQ001-96TESTS
About this Product
- SKU:
- CQ001
- Additional Names:
- CED,Cartilage-inducing factor,DPD1,Differentiation inhibiting factor,LAP,Latency-associated peptide,Prepro transforming growth factor beta 1,TGF beta,TGF beta 1,TGF beta 1 protein,TGF-beta 1 protein,TGF-beta-1,TGF-beta-5,TGF-beta1,TGFB,TGFB1,Tgfb-1,Tgfb1
- Application:
- ELISA
- Extra Details:
- TGFB1 (TGF-B Beta1) is a 44 kDa multifunctional cytokine regulating cell growth, differentiation, migration, immunity, and development. It exists as a latent proprotein, where the Latency-Associated Peptide (LAP) non-covalently binds TGF-B Beta1, maintaining inactivity and storing it in the extracellular matrix. Activation is tightly controlled via interactions of LAP with milieu proteins (LTBP1, GARP, NRROS) and specific integrins (A AlphavB Beta6/A AlphavB Beta8), which induce conformational release of active TGF-B Beta1.Active TGF-B Beta1 signals through TGFBR1/TGFBR2 receptors, inducing SMAD2/3 phosphorylation and regulating gene expression. It modulates immune responses, directing T-cell differentiation toward Treg or Th17 lineages in a concentration-dependent manner. It is crucial for wound healing, bone remodeling, and organogenesis, but its dysregulation is linked to fibrosis, cancer progression, metastasis, atherosclerosis, and autoimmune diseases.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Range:
- 0.16-10 ng/mL
- Reactivities:
- Wide/Non-species Specific
- Sensitivity:
- 0.089 ng/mL
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:p-cellaquant™_tgf_β1_(transforming_growth_factor_beta_1)_elisa_kit-cq001
