Recombinant Histone H2B (Ubiquityl Lys120) Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN302107L-50UL
100 ul
£402.00
AN302107L-100UL
About this Product
- SKU:
- AN302107L
- Additional Names:
- HIST1H2BG;H2B.1A;H2B/a;H2BFA;H2BFL;HIST1H2BC;H2BFH;HIST1H2BE;H2BFG;HIST1H2BF;H2BFK;HIST1H2BI;H2BC4;H2BC6;H2BC7;H2BC8;H2BC10
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A831
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Ubiquitin (Ub) is a highly conserved 76-amino acid protein that plays a critical role in regulating a wide range of cellular processes. Through a three-step process involving Ub-activating (E1), Ub-conjugating (E2), and Ub-ligating (E3) enzymes, ubiquitin covalently attaches to target proteins and marks them for proteasomal degradation, alters protein-protein interactions, modulates membrane protein trafficking, and controls the activity of many signal transduction pathways. Mono-ubiquitination of Histone H2B at Lys120 (H2BK120ub) serves signaling purposes and is reversible by ubiquitin-specific proteases (USPs). The enzymes responsible for H2BK120ub are Rad6 E2 proteins (HR6A and HR6B in human) and Bre1 E3 ligase (RNF20 and RNF40 in human). This modification triggers a "trans-histone" modification cascade, resulting in trimethylation of Lys4 and Lys79 in histone H3, which promotes gene activity.
- Host:
- Rabbit
- Immunogen:
- Ubiquitinated human histone H2B (Lys120) peptide
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_histone_h2b_(ubiquityl_lys120)_monoclonal_antibody-an302107l
