Recombinant Phospho-BTK (Tyr551) Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN302103L-50UL
100 ul
£402.00
AN302103L-100UL
About this Product
- SKU:
- AN302103L
- Additional Names:
- IMD;AGMX;PSCTK;AGMX1;AT;ATK;BPK;IMD1;PSCTK1;XLA;BTK;Bruton tyrosine kinase;AGMX1;ATK;BPK;Bruton tyrosine kinase;IMD1;PSCTK1;XLA
- Application:
- Flow Cytometry
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A827
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains apleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation ofB cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 andTyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 withinthe SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCB Beta through phosphorylation of Btkat Ser180, which results in reduced membrane recruitment, transphosphorylation, and subsequent activation. The PKC inhibitory signal islikely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_phospho_btk_(tyr551)_monoclonal_antibody-an302103l
