Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN302080L-50UL
100 ul
£402.00
AN302080L-100UL
About this Product
- SKU:
- AN302080L
- Additional Names:
- COB;COB1;YAP;YAP2;YAP65;YKI;YAP1;65 kDa Yes associated protein;65 kDa Yes-associated protein;Basic protease inhibitor;BPTI;Pancreatic Trypsin Inhibitor;Trasylol;YAp 1;YAP 65;Yes associated protein 1;Yes associated protein 1 65kDa;Yes associated protein 2;yes associated protein beta;yes -associated protein delta;Yorkie homolog
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A804
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
- Host:
- Rabbit
- Immunogen:
- phosphorylated human YAP1 (Ser1270) peptide
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_phospho_yap1_(ser127)_monoclonal_antibody-an302080l
