Recombinant TRIAD1 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN302043L-50UL
100 ul
£402.00
AN302043L-100UL
About this Product
- SKU:
- AN302043L
- Additional Names:
- ARI;ARIH;TRIAD;ARI2;TRIAD1;ARIH2;HT005;all trans retinoic acid inducible RING finger;Ari 2;Ari-2;Ariadne 2;Ariadne 2 protein homolog;ariadne homolog 2;ariadne homolog 2 (Drosophila);Ariadne RBR E3 ubiquitin protein ligase 2;ARIH 2;E3 ubiquitin protein ligase ARIH2;E3 ubiquitin-protein ligase ARIH2;protein ariadne 2 homolog;Protein ariadne-2 homolog;Triad 1;Triad1 protein;UIP48
- Application:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A763
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The E3 ubiquitin-protein ligase ARIH2 (TRIAD1) is an Ariadne subfamily ligase involved in the polyubiquitination of proteins designated for proteasomal degradation. The TRIAD1 nuclear protein contains an amino-terminal acidic region, a pair of RING fingers, two carboxyl terminal coiled coil domains and a novel C6HC DRIL/IBR domain located between the RING fingers. Together, the paired RING fingers and DRIL/IBR domain form a highly conserved TRIAD (two RING fingers and DRIL) domain. Research studies suggest that TRIAD1 mediates both Lys48 and Lys63 protein polyubiquitination and acts as a negative regulator of myelopoiesis. TRIAD1 ubiquitin ligase inhibits myeloid cell proliferation by mediating protein ubiquitination through the ubiquitin-conjugating enzymes UbcH7 and UbcH13. Experimental deletion of TRIAD1 in mice has a lethal effect, leading to death at the embryonic stage or later due to a severe, multi-organ inflammatory response. Results indicate that TRIAD1 binds IK KappaBB Beta in dendritic cells and promotes the degradation of the NF-K KappaB inhibitor.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_triad1_monoclonal_antibody-an302043l
