Recombinant SHIP-2 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN302029L-50UL
100 ul
£402.00
AN302029L-100UL
About this Product
- SKU:
- AN302029L
- Additional Names:
- SHIP;INPPL;INPPL1;OPSMD;SHIP2;5 trisphosphate 5 phosphatase 2;51C protein;5-trisphosphate 5-phosphatase 2;EC 3.1.3.n1;inositol polyphosphate phosphatase like 1;Inositol polyphosphate phosphatase like protein 1;Inositol polyphosphate phosphatase-like protein 1;INPPL-1;Phosphatidylinositol 3;Protein 51C;SH2 domain containing inositol 5' phosphatase 2;SH2 domain-containing inositol 5''-phosphatase 2;SH2 domain-containing inositol phosphatase 2;SHIP-2
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A749
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif, followed by tyrosine phosphorylation on the NPXY motif. The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1. Its effect on calcium flux, cell survival, growth, cell cycle arrest, and apoptosis is mediated through the PI3K and Akt pathways. Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function.SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta.SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Tyr1135 is phosphorylated in human cancer cells.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_ship_2_monoclonal_antibody-an302029l
