Recombinant PLCG1 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301997L-50UL
100 ul
£402.00
AN301997L-100UL
About this Product
- SKU:
- AN301997L
- Additional Names:
- PLCG;phospholipase C gamma;NCKAP;PLCgamma;PLC;PLCG1;NCKAP3;PLC-II;PLC1;PLC148;PLCgamma1;phospholipase C gamma 1;NCKAP3;phospholipase C gamma 1;PLC1;PLC148;PLCgamma1;PLC-II
- Application:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A717
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling.In response to extracellular stimuli, such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCB Beta, PLCG Gamma, PLCD Delta, and PLCE Epsilon. Phosphorylation is one of the key mechanisms that regulate the activity of PLC. PLCG Gamma is activated by both receptor and non-receptor tyrosine kinases. PLCG Gamma forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCG Gamma at Tyr771, 783, and 1248. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCG Gamma1. PLCG Gamma2 is engaged in antigen dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197, and 1217 is correlated with PLCG Gamma2 activity.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_plcg1_monoclonal_antibody-an301997l
