Recombinant SLC25A12 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301939L-50UL
100 ul
£402.00
AN301939L-100UL
About this Product
- SKU:
- AN301939L
- Additional Names:
- AGC;EIEE;SLC25A;SLC25A12;AGC1;ARALAR;EIEE39;ARALAR1;Araceli hiperlarga;Calcium binding mitochondrial carrier superfamily member;Calcium binding mitochondrial carrier superfamily member Aralar1;Calcium-binding mitochondrial carrier protein Aralar1;CMC1;member 12;Mitochondrial aspartate glutamate carrier 1;solute carrier family 25;Solute carrier family 25 (aspartate/glutamate carrier) member 12;Solute carrier family 25 (mitochondrial carrier Aralar) member 12;Solute carrier family 25 member 12
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A655
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The calcium-binding mitochondrial carrier protein (SLC25A12), also named as ARALAR or AGC1, is an aspartate-glutamate exchange protein responsible for transporting mitochondrial aspartate across the mitochondrial inner membrane in exchange for cytosolic glutamate. SLC25A12 and other proteins of the aspartate-glutamate carrier (AGC) group are required for the transfer of mitochondrial aspartate to the cytosol, a key step in urea synthesis. Research studies using SLC25A12-knockout mice indicate that SLC25A12 plays an important role in proper CNS myelination. Mice lacking SLC25A12 suffer from hypomyelination as a result of a lack of oligodendrocyte maturation caused by decreased brain N-acetylaspartate levels. Mutation of the corresponding SLC25A12 gene can result in global cerebral hypomyelination and severe psychomotor retardation, caused by deficient SLC25A12 activity and limited mitochondrial aspartate efflux.
- Host:
- Rabbit
- Immunogen:
- Recombinant human SLC25A12 fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_slc25a12_monoclonal_antibody-an301939l
