Recombinant TMS1/ASC Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301903L-50UL
100 ul
£402.00
AN301903L-100UL
About this Product
- SKU:
- AN301903L
- Additional Names:
- CARD;ASC / TMS;PYCARD;ASC;CARD5;TMS;TMS-1;TMS1;PYD and CARD domain containing;ASC / TMS1;Apoptosis associated speck like protein containing a CARD;Apoptosis-associated speck-like protein containing a CARD;CARD 5;Caspase recruitment domain containing protein 5;Caspase recruitment domain protein 5;Caspase recruitment domain-containing protein 5;hASC;MGC10332;PYD and CARD domain containing protein;PYD and CARD domain-containing protein;Target of methylation induced silencing 1;Target of methylation-induced silencing 1;TMS 1
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A619
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Target of methylation-induced silencing (TMS1)/Apoptosis-associated speck-like protein containing a CARD (ASC), also referred to as PYCARD and CARD5, is a 22-kDa pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD). The ASC/TMS1 gene was originally found to be aberrantly methylated and silenced in breast cancer cells, and has since been found to be silenced in a number of other cancers, including ovarian cancer, glioblastoma, melanoma, gastric cancer, lung cancer, and prostate cancer. Expression of ASC/TMS1 can be induced by pro-apoptotic/inflammatory stimuli. During apoptosis ASC/TMS1 is re-distributed from the cytosol to the mitochondria and associates with mitochondrial Bax to trigger cytochrome c release and subsequent apoptosis. ASC/TMS1 has also been found to be a critical component of inflammatory signaling where it associates with and activates caspase-1 in response to pro-inflammatory signals.
- Host:
- Rabbit
- Immunogen:
- Recombinant human TMS1/ASC fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:asc_monoclonal_antibody-an301903l
