Recombinant Gelsolin Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301896L-50UL
100 ul
£402.00
AN301896L-100UL
About this Product
- SKU:
- AN301896L
- Additional Names:
- DKFZp313L;GSN;ADF;AGEL;gelsolin;Actin depolymerizing factor;DKFZp313L0718;Brevin;GELS;Actin-depolymerizing factor;Actin-depolymerizing factor;ADF;AGEL;Brevin;GELS;GSN
- Application:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A612
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Gelsolin also named as actin-depolymerizing factor, ADF, AGEL or Brevin, is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin. Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner. Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling. Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation. In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition.
- Host:
- Rabbit
- Immunogen:
- Recombinant human Gelsolin fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_gelsolin_monoclonal_antibody-an301896l
