Recombinant Cdc25C Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301883L-50UL
100 ul
£402.00
AN301883L-100UL
About this Product
- SKU:
- AN301883L
- Additional Names:
- CDC;PPP1R;CDC25C;CDC25;PPP1R60
- Application:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A595
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Cdc25C is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. Cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint. When phosphorylated at Ser216, Cdc25C binds to members of the 14-3-3 family of proteins, sequestering Cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 phosphorylate Cdc25C at Ser216 in response to DNA damage.
- Host:
- Rabbit
- Immunogen:
- Recombinant human Cdc25C fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_cdc25c_monoclonal_antibody-an301883l
