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Antibodies

Recombinant TPX2 Monoclonal Antibody

Product Sizes
50 ul
£281.00
AN301679L-50UL
100 ul
£402.00
AN301679L-100UL
About this Product
SKU:
AN301679L
Additional Names:
FLS;HCA;TPX;HCTP;REPP;GD:C20orf;DIL;DIL2;p100;DIL-2;HCTP4;FLS353;HCA519;REPP86;C20orf1;C20orf2;GD:C20orf1;TPX2;Chromosome 20 Open Reading Frame 1;Differentially expressed in cancerous and noncancerous lung cells 2;Differentially expressed in cancerous and non-cancerous lung cells 2;Differentially expressed in lung cells;Differentially expressed in lung cells 2;DIL 2;HCA 519;HCTP 4;Hepatocellular carcinoma associated antigen 519;Hepatocellular carcinoma-associated antigen 519;Preferentially expressed in colorectal cancer;Protein fls353;REPP 86;Restricted expression proliferation associated protein 100;Restricted expression proliferation-associated protein 100;Targeting protein for Xklp2;TPX 2;TPX2 microtubule associated homolog;TPX2 microtubule associated protein homolog;TPX2 microtubule nucleation factor
Application:
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
translate.label.attr.clone:
A382
Clonality:
Recombinant Monoclonal
Concentration:
1 mg/ml
Extra Details:
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
Host:
Rabbit
Immunogen:
Recombinant human TPX2 fragment
Isotype:
IgG, kappa
Purification:
Protein A Purified
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Recombinant Antibodies
Immunohistochemistry of paraffin-embedded Mouse small intestine using TPX2 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Rat colon using TPX2 Monoclonal Antibody at dilution of 1:50.
Immunofluorescent analysis of (4% Paraformaldehyde) fixed Hela cells using anti-TPX2 Monoclonal Antibody at dilution of 1:50.
Immunofluorescent analysis of (4% Paraformaldehyde) fixed RAW 264.7 cells using anti-TPX2 Monoclonal Antibody at dilution of 1:50.
Flow cytometric analysis of human TPX2 expression on Hela cells. Cells were stained with purified anti-Human TPX2, then a Alexa Fluor 488-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells.