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Antibodies

Recombinant HMGCR Monoclonal Antibody

Product Sizes
50 ul
£281.00
AN301555L-50UL
100 ul
£402.00
AN301555L-100UL
About this Product
SKU:
AN301555L
Additional Names:
LDLCQ;HMGCR;LDLCQ3;3-hydroxy-3-methylglutaryl-CoA reductase;3-hydroxy-3-methylglutaryl-CoA reductase;LDLCQ3;3-hydroxy-3-methylglutaryl-coenzyme A reductase;HMG-CoA reductase
Application:
Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
translate.label.attr.clone:
A254
Clonality:
Recombinant Monoclonal
Concentration:
1 mg/ml
Extra Details:
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative feedback, in which cholesterol and other end products of the metabolic pathway inhibit the activity of HMGCR in a multivalent manner. Cholesterol inhibits reductase activity mainly by inhibiting the transcription rate of HMGCR gene. HMGCR is the main target of statins, which are a class of cholesterol-lowering drugs.
Host:
Rabbit
Immunogen:
Recombinant human HMG-CoA Reductase fragment
Isotype:
IgG, kappa
Purification:
Protein A Purified
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Recombinant Antibodies
Western Blot with HMGCR Monoclonal Antibody at dilution of 1:2000. Lane 1: Jurkat, Lane 2: HepG2
Immunofluorescent analysis of (4% Paraformaldehyde) fixed NIH-3T3 cells using anti-HMGCR Monoclonal Antibody at dilution of 1:50.
Flow cytometric analysis of human HMGCR expression on HepG2 cells. Cells were stained with purified anti-Human HMGCR, then a Alexa Fluor 488-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells.
Immunoprecipitation analysis using anti-HMGCR Monoclonal Antibody. Western blot was performed from the immunoprecipitate using HMGCR Monoclonal Antibody at a dilution of 1:25. Lane 1: 5% Input, Lane 2: HMGCR Monoclonal Antibody, Lane 3: Rabbit monoclonal IgG Isotype