Recombinant Cyclin D3 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301504L-50UL
100 ul
£402.00
AN301504L-100UL
About this Product
- SKU:
- AN301504L
- Additional Names:
- G1 S specific cyclin D;G1/S specific cyclin D;G1/S-specific cyclin-D;CyclinD;cyclin D;CCND3;cyclin D3;CCND 3;CyclinD3;D3 type cyclin;G1 S specific cyclin D3;G1/S specific cyclin D3;G1/S-specific cyclin-D3
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A203
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Host:
- Rabbit
- Immunogen:
- Recombinant human Cyclin D3 fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_cyclin_d3_monoclonal_antibody-an301504l
