Recombinant CD33 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301475L-50UL
100 ul
£402.00
AN301475L-100UL
About this Product
- SKU:
- AN301475L
- Additional Names:
- CD33;SIGLEC-3;SIGLEC3;p67;CD33 molecule;gp67;Myeloid cell surface antigen CD33;Sialic acid-binding Ig-like lectin 3;Siglec-3;CD33 molecule;p67;SIGLEC3
- Application:
- Immunohistochemistry
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A170
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules.
- Host:
- Rabbit
- Immunogen:
- Recombinant human CD33 fragment
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_cd33_monoclonal_antibody-an301475l
