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Antibodies

Recombinant CD25 Monoclonal Antibody

Product Sizes
50 ul
£281.00
AN301472L-50UL
100 ul
£402.00
AN301472L-100UL
About this Product
SKU:
AN301472L
Additional Names:
IMD;IDDM;IL2RA;CD25;IDDM10;IL2R;IMD41;TCGFR;p55;IL-2 receptor subunit alpha;IL-2R subunit alpha;IL2-RA;IL-2-RA;IL-2RA Alpha;Interleukin-2 receptor subunit alpha;TAC antigen;Tac;p55;IL-2Rαalpha chain;CD25 antigen;IL 2 receptor alpha subunit;IL2 RA;Interleukin 2 receptor;Interleukin 2 receptor alpha;Interleukin 2 receptor alpha chain;t-cell growth factor receptor
Application:
Flow Cytometry, Immunofluorescence
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
translate.label.attr.clone:
A167
Clonality:
Recombinant Monoclonal
Concentration:
1 mg/ml
Extra Details:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
Host:
Rabbit
Immunogen:
Recombinant human CD25 fragment
Isotype:
IgG, kappa
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Recombinant Antibodies
Immunofluorescent analysis of (4% Paraformaldehyde) fixed Jurkat cells using anti-CD25 Monoclonal Antibody at dilution of 1:50.
Immunofluorescent analysis of (4% Paraformaldehyde) fixed K562 cells using anti-CD25 Monoclonal Antibody at dilution of 1:50.
Flow cytometric analysis of human CD25 expression on Jurkat cells. Cells were stained with purified anti-Human CD25, then a Alexa Fluor 488-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells.