Recombinant PD1 Monoclonal Antibody
Product Sizes
50 ul
£281.00
AN301420L-50UL
100 ul
£402.00
AN301420L-100UL
About this Product
- SKU:
- AN301420L
- Additional Names:
- SLEB;hSLE;Programmed Death;programmed cell death;Programmed cell death protein;Systemic lupus erythematosus susceptibility;hPD;PDCD1;CD279;PD-1;PD1;SLEB2;hPD-1;hPD-l;hSLE1;programmed cell death 1;PD 1;CD279 antigen;hPD 1;hPD l;PDCD 1;Programmed cell death 1 protein;Programmed Death-1;Protein PD 1;Protein PD-1;Systemic lupus erythematosus susceptibility 2;Programmed cell death protein 1;CD279;CD279 antigen;hPD 1;hPD l;hPD-1;hSLE1;PD 1;PD-1;PD1;PDCD 1;PDCD1;PDCD1;Programmed cell death 1;Programmed cell death 1 protein;Programmed cell death protein 1;Protein PD 1;Protein PD-1;SLEB2;Systemic lupus erythematosus susceptibility 2
- Application:
- Immunofluorescence, Immunohistochemistry
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A115
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide derived from the human PD1 protein
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_pd1_monoclonal_antibody-an301420l
