Recombinant MMP9 Monoclonal Antibody
Product Sizes
100 ul
£346.00
AN301378L-100UL
About this Product
- SKU:
- AN301378L
- Additional Names:
- IBP;Matrix metalloproteinase;B/MMP;Igfbp;MANDP;92 kDa gelatinase;92 kDa type IV collagenase;92kDa Type IV Collagenase;AW743869;B/MMP9;Gelatinase B;GELB;IBP6;IGFBP6;MANDP2;Matrix metalloproteinase-9;MMP-9;pro-MMP-9;Clg4b;Mmp9;92 KDa Gelatinase;92kDa Type IV Collagenase;CLG4B;GELB;MANDP2;CLG4B;Gelatinase B;MMP-9
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- B1145
- Clonality:
- Monoclonal, Recombinant Monoclonal
- Concentration:
- 0.2 mg/ml
- Extra Details:
- Cleavage of gelatin types I and V and collagen types IV and V.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).,May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.,induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.,miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.,PTM:N- and O-glycosylated.,PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 3 fibronectin type-II domains.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.,tissue specificity:Produced by normal alveolar macrophages and granulocytes.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse MMP9 protein
- Isotype:
- IgG, kappa
- Purification:
- Protein A Purified
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_mmp9_monoclonal_antibody-an301378l
