Recombinant TROP-2/TACSTD2 Monoclonal Antibody
Product Sizes
20 ul
£189.00
AN300566P-20UL
100 ul
£402.00
AN300566P-100UL
About this Product
- SKU:
- AN300566P
- Additional Names:
- EGP,Cell surface glycoprotein Trop,Tumor-associated calcium signal transducer,GA733,TACSTD,C80403,Cell surface glycoprotein Trop-2,EGP-1,GA733-1,Ly97,TROP-2,Tumor-associated calcium signal transducer 2,Trop2,Tacstd2
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- B501
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse TROP-2/TACSTD2 protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:tacstd2_monoclonal_antibody-an300566p
