Recombinant CD23/FCER2 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300547P-100UL
About this Product
- SKU:
- AN300547P
- Additional Names:
- Fce;FCER;CD23;Fce2;Fc-epsilon-RII;Ly-42;Lymphocyte IgE receptor;Fcer2a;Fcer2;Fc&epsilon-RII-I;Ly-42;BLAST-2;CD23A;CLEC4J;Fc epsilon RII;IGEBF
- Application:
- Flow Cytometry, Immunocytochemistry, Immunofluorescence
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- B477
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD23, also known as FcE EpsilonRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family. CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells. CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes. CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3'5'-monophosphate (cAMP). Soluble CD23 signals through integrins, activating MAPK and NF-K KappaB pathways. CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL).
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse CD23/FCER2 Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:fcer2_monoclonal_antibody-an300547p
