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Antibodies

Recombinant SIGNR1/CD209b Monoclonal Antibody

Product Sizes
100 ul
£402.00
AN300523P-100UL
About this Product
SKU:
AN300523P
Additional Names:
OtB;DC-SIGN-related protein;DC-SIGNR;CD209;CD209 antigen-like protein B;DC-SIGNR1;DC-SIGN-related protein 1;OtB7;Cd209b
Application:
Immunocytochemistry, Immunofluorescence
Buffer:
0.2 um filtered solution in PBS
translate.label.attr.clone:
B453
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.
Host:
Rabbit
Immunogen:
Recombinant Mouse SIGNR1/CD209b protein
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Immunofluorescence analysis of Mouse CD209B in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse CD209B monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green).
Flow cytometric analysis of Mouse CD209b expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD209b, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.