Recombinant IGFBP6/IBP6 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300520N-100UL
About this Product
- SKU:
- AN300520N
- Additional Names:
- IGF-binding protein;IGF binding protein;ERBB;ErbB1;ErbB-1;IBP6;IGF binding protein 6;Insulin-like growth factor-binding protein 6;mENA;IBP-6;IGFBP-6;IGF-binding protein 6;IGFBP6
- Application:
- IHC-Paraffin
- Buffer:
- 0.2 um filtered solution in 20 mM MES, 100 mM NaCl, 10% Trehalose, pH 6.0
- translate.label.attr.clone:
- B450
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Mouse IGFBP-6 cDNA encodes a 238 amino acid (aa) residue precursor protein with a putative 25 aa residue signal peptide that is processed to generate the 213 aa residue mature protein that is O-glycosylated. Mouse and human IGFBP-6 share 73% amino acid similarity. Mouse and rat IGFBP-6 share 94% amino acid similarity and the mouse IGFBP-6 has a 9 amino acid insertion compared to the rat homolog. IGFBP-6 is expressed in ovarian, testicular, muscle, heart and lung tissues in the adult mouse. IGFBP-6 was not detected in total RNA from a whole mouse embryo.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse IGFBP6/IBP6 Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:ibp6_monoclonal_antibody-an300520n
