Recombinant CD4 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300482P-100UL
About this Product
- SKU:
- AN300482P
- Additional Names:
- L3T;T-cell surface antigen T4/Leu;T-cell surface glycoprotein CD;L3T4;Ly-4;T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;Cd4;L3T4;CD4mut;p55
- Application:
- Flow Cytometry, Immunocytochemistry, Immunofluorescence
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- B412
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse CD4 Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-recombinant_cd4_monoclonal_antibody-an300482p
