Recombinant BCL2L1/Bcl-XL Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300456P-100UL
About this Product
- SKU:
- AN300456P
- Additional Names:
- bcl2-L;Bcl(X)L;bcl2-L-1;bcl-x;Bcl-XL;Bcl2l;Bclx;Bcl2l1
- Application:
- Immunoprecipitation, Western Blot
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- B382
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apoptosis independent of additional signals. The crystal and solution structures of a Bcl-2 family member, Bcl-xL is like this: The structures consist of two central, primarily hydrophobic A Alpha-helices, which are surrounded by amphipathic helices. A 60-residue loop connecting helices A Alphal and A Alpha2 was found to be flexible and non-essential for anti-apoptotic activity. Bcl-xL is characterized as an important factor in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca2+ to regulate both autophagy and apoptosis. Bcl-xL is also implicated in anoxia induced cell death. The pathway is initiated by the loss of function of the prosurvival Bcl-2 family members Mcl-1 and Bcl-2/Bcl-XL, resulting in Bax- or Bak-dependent release of cytochrome c and subsequent caspase-9-dependent cell death. Thus, Bcl-xL, the well-characterized apoptosis guards, appears to be important in cell death.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse BCL2L1/Bcl-XL Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:bcl_xl_monoclonal_antibody-an300456p
