Recombinant OTUB2 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300435P-100UL
About this Product
- SKU:
- AN300435P
- Additional Names:
- OTB,OTU,OTUB,Ubiquitin Thioesterase OTUB,Deubiquitinating Enzyme OTUB,Ubiquitin-Specific-Processing Protease OTUB,OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein,C14orf,Otubain,Deubiquitinating Enzyme OTUB2,OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein 2,Otubain-2,Ubiquitin Thioesterase OTUB2,Ubiquitin-Specific-Processing Protease OTUB2,C14orf137,OTB2,OTU2,OTUB2,FLJ21916,MGC3102,OTU domain,OTU domain containing ubiquitin aldehyde binding protein 2,OTU domain-containing ubiquitin aldehyde-binding protein 2,Otubain 2,ubiquitin aldehyde binding 2,Ubiquitin specific processing protease OTUB2,Ubiquitin specific protease otubain 2
- Application:
- Immunocytochemistry, Immunofluorescence
- Buffer:
- PBS
- translate.label.attr.clone:
- B361
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded B Beta-sheet sandwiched in between a small helical amino-terminal region consisting of A Alpha1 and A Alpha2, and a large helical region comprised of A Alpha3-A Alpha10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human OTUB2 Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-recombinant_otub2_monoclonal_antibody-an300435p
