Recombinant OTUB2 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300435P-100UL
About this Product
- SKU:
- AN300435P
- Additional Names:
- OTB;OTU;OTUB;Ubiquitin Thioesterase OTUB;Deubiquitinating Enzyme OTUB;Ubiquitin-Specific-Processing Protease OTUB;OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein;C14orf;Otubain;Deubiquitinating Enzyme OTUB2;OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein 2;Otubain-2;Ubiquitin Thioesterase OTUB2;Ubiquitin-Specific-Processing Protease OTUB2;C14orf137;OTB2;OTU2;OTUB2;FLJ21916;MGC3102;OTU domain;OTU domain containing ubiquitin aldehyde binding protein 2;OTU domain-containing ubiquitin aldehyde-binding protein 2;Otubain 2;ubiquitin aldehyde binding 2;Ubiquitin specific processing protease OTUB2;Ubiquitin specific protease otubain 2
- Application:
- Immunocytochemistry, Immunofluorescence
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- B361
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded B Beta-sheet sandwiched in between a small helical amino-terminal region consisting of A Alpha1 and A Alpha2, and a large helical region comprised of A Alpha3-A Alpha10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human OTUB2 Protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:p-recombinant_otub2_monoclonal_antibody-an300435p
