Recombinant SNCA/alpha-Synuclein Monoclonal Antibody
Product Sizes
20 ul
£189.00
AN300413P-20UL
100 ul
£402.00
AN300413P-100UL
About this Product
- SKU:
- AN300413P
- Additional Names:
- Fetal liver kinase;Protein-tyrosine kinase receptor flk;Vascular endothelial growth factor receptor;PD1;NACP;PARK1;PARK4;SNCA;SNC-A;aSYN;CD309;Fetal liver kinase 1;FLK1;FLK-1;KDR;Kinase insert domain receptor;Protein-tyrosine kinase receptor flk-1;Vascular endothelial growth factor receptor 2;VEGFR;VEGFR2;VEGFR-2;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;alpha (non A4 component of amyloid precursor);Alpha synuclein;alphaSYN;isoform NACP140;Lewy body) 4;MGC105443;MGC110988;MGC127560;MGC64356;Non A beta component of AD amyloid;Non A4 component of amyloid;Non A4 component of amyloid precursor;Non-A4 component of amyloid;Non-A-beta component of alzheimers disease amyloid;OTTHUMP00000218549;OTTHUMP00000218551;OTTHUMP00000218552;OTTHUMP00000218553;OTTHUMP00000218554;PARK 1;PARK 4;Parkinson disease (autosomal dominant;Parkinson disease familial 1;precursor of;Snca synuclein;SYN;Synuclein;Synuclein alpha;Synuclein alpha 140;SYUA
- Application:
- Western Blot
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- 5D12
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human SNCA/alpha-Synuclein protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:alpha_synuclein_monoclonal_antibody-an300413p
