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Antibodies

Recombinant beta-Catenin/CTNNB1 Monoclonal Antibody

Product Sizes
100 ul
£402.00
AN300396P-100UL
About this Product
SKU:
AN300396P
Additional Names:
MRD,PRO,Catenin beta,SW-cl,OK/SW-cl,CTNNB,MRD19,armadillo,beta Catenin,CTNNB1,Beta-catenin,Catenin beta-1,OK,SW-cl.35,OK/SW-cl.35,PRO2286,88kDa,beta 1,Cadherin associated protein,Catenin (cadherin associated protein),Catenin beta 1,CATNB,CHBCAT,CTNB1,DKFZp686D02253,FLJ25606,FLJ37923,OTTHUMP00000162082,OTTHUMP00000165222,OTTHUMP00000165223,OTTHUMP00000209288,OTTHUMP00000209289
Application:
Flow Cytometry, IHC-Paraffin, Immunocytochemistry, Immunofluorescence
Buffer:
PBS
translate.label.attr.clone:
B322
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Host:
Rabbit
Immunogen:
Recombinant Human beta-Catenin/CTNNB1 protein
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Immunofluorescence analysis of Human CTNNB1 in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human CTNNB1 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cells membrane.
Immunohistochemistry of paraffin-embedded human skin using beta-Catenin/CTNNB1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded human colon using beta-Catenin/CTNNB1 Monoclonal Antibody at dilution of 1:200.
Flow cytometric analysis of Human CTNNB1 (B Beta-Catenin) expression on Hela cells. The cells were treated according to manufacturer's manual, stained with purified anti-Human CTNNB1 (B Beta-Catenin), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.