Recombinant Nicastrin/NCSTN Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300391P-100UL
About this Product
- SKU:
- AN300391P
- Additional Names:
- UNQ;PRO;ATAG;KIAA;RP11 517F;Anterior pharynx defective;RP11517F;NCSTN;ATAG1874;nicastrin;Anterior pharynx defective 2;APH 2;APH2;NCT;NICA;RP11 517F10.1;RP11517F101;KIAA0253;UNQ1874;PRO4317;RP11-517F10.1
- Application:
- Immunoprecipitation, Western Blot
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- B317
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Nicastrin/NCSTN protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ncstn_monoclonal_antibody-an300391p
