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Antibodies

Recombinant SOD2 Monoclonal Antibody

Product Sizes
100 ul
£402.00
AN300260P-100UL
About this Product
SKU:
AN300260P
Additional Names:
SOD;MVCD;superoxide dismutase;IPO-B;IPOB;MNSOD;MVCD6;Mn-SOD;SOD2;Superoxide Dismutase [Mn] Mitochondrial;superoxide dismutase 2;IPOB;IPO-B;MNSOD;Mn-SOD;MVCD6;superoxide dismutase 2;EC:1.15.1.1;mitochondrial;Superoxide dismutase [Mn]
Application:
Immunoprecipitation, Western Blot
Buffer:
0.2 um filtered solution in PBS
translate.label.attr.clone:
B178
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
Superoxide Dismutases (SODs), originally identified as Indophenoloxidases (IPOs), are enzymes that catalyze the conversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 2 (SOD2), also known as Manganese (Mn) SOD, mitochondrial SOD, and IPO-B, is an intramitochondrial 22 kDa homotetramer. Each SOD2 monomer binds one Mn2+ ion. Three isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SOD2 shares only 23% and 17% sequence identity with SOD1 and SOD3, respectively. SOD2 is, however, well conserved from species to species and shares 90% and 87% homology with mouse and rat SOD2, respectively. Oxidative stress has been implicated in many diseases and the chief source of reactive oxygen species within the cell is the mitochondrion. SOD2 is a free radical scavenging enzyme that protects against damage from superoxide produced as a byproduct of oxidative phosphorylation. SOD2 is required for normal biologic function of tissues by maintaining the integrity of mitochondrial enzymes susceptible to inactivation by superoxide. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
Host:
Rabbit
Immunogen:
Recombinant Human SOD2 protein
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Immunoprecipitation analysis using 2 uL anti-SOD2 Monoclonal Antibody and 15 ul of 50 % Protein G agarose. Western blot was performed from the immunoprecipitate using SOD2 Monoclonal Antibody at a dilution of 1:100. Lane A:0.5 mg Hela Whole Cell Lysate, Lane B:0.5 mg HepG2 Whole Cell Lysate
Western Blot with SOD2 Monoclonal Antibody at dilution of 1:10000. Lane A: Hela Whole Cell Lysate, Lysates/proteins at 30 ug per lane.
Western Blot with SOD2 Monoclonal Antibody at dilution of 1:500. Lane A: Hela Whole Cell Lysate, Lane B: SOD2 konckout Hela Whole Cell Lysate, Lysates/proteins at 30 ug per lane.