Recombinant BLyS/TNFSF13B/BAFF Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300173P-100UL
About this Product
- SKU:
- AN300173P
- Additional Names:
- UNQ;PRO;ZTNF;TNF- and APOL-related leukocyte expressed ligand;TNFSF;TNFSF13B;BAFF;BLYS;CD257;DTL;TALL-1;TALL1;THANK;TNFSF20;TNLG7A;ZTNF4;Tumor necrosis factor ligand superfamily member 13B;B lymphocyte stimulator;B-cell-activating factor;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;UNQ401;PRO738;BAFF;TNFSF13b;TALL-1;ApoL related ligand TALL 1;B cell Activating Factor;CD 257;CD257 antigen;Delta BAFF;Dendritic cell derived TNF like molecule;DTL precursor;soluble form;TALL 1;TN13B;TNF and APOL related leukocyte expressed ligand 1;TNF homolog that activates apoptosis;TNF homolog that activates apoptosis NKFB and JNK.;Tumor necrosis factor (ligand) superfamily member 13b;Tumor necrosis factor ligand 7A;Tumor necrosis factor ligand superfamily member 20;Tumor necrosis factor like protein ZTNF4;Tumor necrosis factor superfamily member 13B
- Application:
- Flow Cytometry, Immunoprecipitation, Western Blot
- Buffer:
- 0.2 um filtered solution in PBS
- translate.label.attr.clone:
- A1287
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine. BAFF may also further oligomerize into 60-mer structures. BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells. BAFF plays a key role in B cell development, survival, and activation. BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA. These receptors are differentially expressed during B cell development and among B cell subsets. While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures. The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-K KappaB pathways, PI3K/Akt, and mTOR. Activation of the noncanonical NF-K KappaB pathway via BAFF-R is negatively regulated by TRAF3. Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human BLyS / TNFSF13B / BAFF protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:baff_monoclonal_antibody-an300173p
