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Antibodies

Recombinant Phospho-Stat3 (Tyr705) Monoclonal Antibody

Product Sizes
20 ul
£189.00
AN300142P-20UL
100 ul
£402.00
AN300142P-100UL
About this Product
SKU:
AN300142P
Additional Names:
STAT;Signal Transducer and Activator of Transcription;ADMIO;ADMIO1;APRF;HIES;STAT3;Acute-Phase Response Factor;Signal Transducer and Activator of Transcription 3;1110034C02Rik;Acute Phase Response Factor;AW109958;DNA binding protein APRF;FLJ20882;MGC16063;Signal transducer and activator of transcription 3 (acute phase response factor);STAT 3
Application:
Western Blot
Buffer:
0.2 um filtered solution in PBS
translate.label.attr.clone:
4B8
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Host:
Rabbit
Immunogen:
A synthetic phosphopeptide corresponding to residues around Tyr705 of the Human Phospho-Stat3
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with IFNA Alpha (150 ng/mL, 15 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-Stat3 (Tyr705) Monoclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts from serum-starved Hela, untreated (-) and treated with IFN alpha 2 (150 ng/mL, 15 min) (+) using Phospho-Stat3 (Tyr705) Monoclonal Antibody at 1:1000 dilution or Beta-Tubulin Loading Control Antibody, Mouse Mab at 1:20000 dilution (lower).
Western blot analysis of extracts from serum-starved Hela treated with IFNA Alpha (150 ng/mL, 15 min), using Phospho-Stat3 (Tyr705) Monoclonal Antibody and other brands' antibodies (Company C) at dilution of 1:2000, 1:10000 and 1:50000.