Recombinant MMP-2 Monoclonal Antibody
Product Sizes
100 ul
£402.00
AN300112P-100UL
About this Product
- SKU:
- AN300112P
- Additional Names:
- TBE,CLG,Matrix Metalloproteinase,MMP,CLG4,CLG4A,MMP-2,MMP-II,MONA,TBE-1,MMP2,72 kDa Gelatinase,72 kDa Type IV Collagenase,Gelatinase A,Matrix Metalloproteinase-2,72kD type IV collagenase,72kDa gelatinase,72kDa type IV collagenase),CLG 4,CLG 4A,Collagenase Type 4 alpha,Collagenase type IV A,Gelatinase alpha,Gelatinase neutrophil,Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase,Matrix Metalloproteinase 2,Matrix metalloproteinase 2 (gelatinase A,Matrix metalloproteinase II,MMP 2,MMP II,Neutrophil gelatinase,PEX,TBE 1
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- A1226
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human MMP-2 protein
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:p-recombinant_mmp_2_monoclonal_antibody-an300112p
