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Antibodies

Recombinant FDPS/Farnesyl Diphosphate Synthase Monoclonal Antibody

Product Sizes
20 ul
£189.00
AN300076P-20UL
100 ul
£402.00
AN300076P-100UL
About this Product
SKU:
AN300076P
Additional Names:
KIAA;POROK;FDPS;FPPS;FPS;POROK9;Dimethylallyltranstransferase;Farnesyl diphosphate synthase;Farnesyl diphosphate synthetase;Farnesyl pyrophosphate synthase;Farnesyl pyrophosphate synthetase;FPP synthase;FPP synthetase;FPPS_HUMAN;Geranyltranstransferase;KIAA1293
Application:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Buffer:
0.2 um filtered solution in PBS
translate.label.attr.clone:
A1186
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 18 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Host:
Rabbit
Immunogen:
Recombinant Human FDPS / Farnesyl Diphosphate Synthase protein
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Flow cytometric analysis of Human FDPS expression on HeLa cells. The cells were stained with purified anti-Human FDPS, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Immunofluorescence analysis of Human FDPS in HUVEC cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human FDPS Monoclonal Antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI for nuclear staining (blue). Positive staining was localized to cytoplasm.
Immunoprecipitation analysis using 2 uL anti-FDPS Monoclonal Antibody and 15 ul of 50 % Protein G agarose. Western blot was performed from the immunoprecipitate using FDPS Monoclonal Antibody at a dilution of 1:100. Lane A:0.5 mg Hela Whole Cell Lysate, Lane B:0.5 mg HepG2 Whole Cell Lysate, Lane C:0.5 mg A549 Whole Cell Lysate
Western Blot with FDPS / Farnesyl Diphosphate Synthase Monoclonal Antibody at dilution of 1:500. Lane A: HepG2 Whole Cell Lysate, Lane B: Hela Whole Cell Lysate, Lysates/proteins at 30 ug per lane.