Recombinant Phospho-HER3/ErbB3 (Tyr1289) Monoclonal Antibody
Product Sizes
20 ul
£189.00
AN300020L-20UL
100 ul
£402.00
AN300020L-100UL
About this Product
- SKU:
- AN300020L
- Additional Names:
- HER;LCCS;Proto-oncogene-like protein c-ErbB;Tyrosine kinase-type cell surface receptor HER;MDA-BF;p180-ErbB;p45-sErbB;p85-sErbB;ERBB3;ErbB-3;HER3;LCCS2;MDA-BF-1;c-erbB-3;c-erbB3;erbB3-S;p180-ErbB3;p45-sErbB3;p85-sErbB3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3;EEBB3
- Application:
- Western Blot
- Buffer:
- 10 mM sodium HEPES, 150 mM NaCl, 100 ug/mL protein protectant, 50% glycerol, pH 7.5
- translate.label.attr.clone:
- A1130
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
- Host:
- Rabbit
- Immunogen:
- A synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3
- Isotype:
- IgG
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:erbb3_(tyr1289)_monoclonal_antibody-an300020l
