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Antibodies

Recombinant Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody

Product Sizes
20 ul
£189.00
AN300005L-20UL
100 ul
£402.00
AN300005L-100UL
About this Product
SKU:
AN300005L
Additional Names:
TKR;ERBB;erb-b2 receptor tyrosine kinase;Receptor tyrosine-protein kinase erbB;Tyrosine kinase-type cell surface receptor HER;HER2/ErbB;HER;MLN;ERBB2;CD340;HER-2;HER-2/neu;HER2;MLN 19;NEU;NGL;TKR1;erb-b2 receptor tyrosine kinase 2;HER2/ErbB2;MLN19;Metastatic lymph node gene 19 protein;p185;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2;Tyrosine kinase-type cell surface receptor HER2;Neu;erb-B2;CD340;erb-b2 receptor tyrosine kinase 2;HER2;HER-2;HER-2/neu;MLN 19;MLN19;NGL;TKR1;C erb B2/neu protein;CD340 antigen;Cerb B2/neu protein;CerbB2;ENV;ENVW;Erb b2 receptor tyrosine kinase 2;ERVWE1;HER 2;HER 2/NEU;Herstatin;HERV7Q;HERV-7q;HERVW;HERVWENV;HERV-W-ENV;Human epidermal growth factor receptor 2;NEU proto oncogene;neuro/glioblastoma derived oncogene homolog;neuro/glioblastoma derived oncogene homolog (avian);Neuroblastoma/glioblastoma derived oncogene homolog;p185erbB2;Proto-oncogene c-ErbB-2;Tyrosine kinase type cell surface receptor HER2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog);V erb b2 avian erythroblastic leukemia viral oncoprotein 2;V erb b2 erythroblastic leukemia viral oncogene homolog 2;Verb b2 erythroblastic leukemia viral oncogene homolog 2
Application:
Western Blot
Buffer:
10 mM sodium HEPES, 150 mM NaCl, 100 ug/mL protein protectant, 50% glycerol, pH 7.5
translate.label.attr.clone:
A1115
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.
Host:
Rabbit
Immunogen:
A synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2.
Isotype:
IgG
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Western blot analysis of extracts from serum-starved SkBr3, untreated (-) or treated with EGF (Cat: PKSH031641) (200 ng/mL, 10 min; +), using Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody at 1:200000 dilution (upper) or Anti-Her2/ERBB2 Antibody, Mouse Monoclonal at 1:500 dilution (lower).
Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (Cat: PKSH031641) (200 ng/mL, 10 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody at 1:200000 dilution.
Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (Cat: PKSH031641) (200 ng/mL, 10 min) (line B); treated with EGF and L Lambda-phosphatase (line C) using Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody at 1:200000 dilution.
Western blot analysis of extracts from serum-starved SkBr3, treated with EGF (Cat: PKSH031641) (200 ng/mL, 10 min), using Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody and other brands' antibodies (Company C) at dilution of 1:300000, 1:100000 and 1:10000.